Analysis performed on 2024-09-30 10:20:59
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 42718 | 523 | 42195 | 26446 |
| Archaea | 3027 | 81 | 2946 | 1257 |
| Vertebrata | 1192 | 357 | 835 | 411 |
| Mammals | 577 | 90 | 487 | 134 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 514 | 9 | 285 |
| Domains | |
|---|---|
| Current Study | 475, 515 |
| Guo et al (2010) | 461, 514 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 473 | 41 | 514 | 11.536585 |
| Number of Variants | 266 | 28 | 294 | 9.5 |
| Number of Pathogenic Variants | 9 | 0 | 9 | Undefined |
| Number of Benign/Unknown Variants | 257 | 28 | 285 | 9.178571 |
| Fisher exact test | 1.0 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 460 | 54 | 514 | 8.518519 |
| Number of Variants | 254 | 40 | 294 | 6.35 |
| Number of Pathogenic Variants | 9 | 0 | 9 | Undefined |
| Number of Benign/Unknown Variants | 245 | 40 | 285 | 6.125 |
| Fisher exact test | 0.615238 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 473 | 41 | 0.89 (0.01) | 0.76 (0.03) | 9.252e-01 | 7.806e-01 | 13514.00 | 1.43e-05 |
| Guo et al (2010) | 460 | 54 | 0.89 (0.01) | 0.78 (0.02) | 9.256e-01 | 8.147e-01 | 17071.00 | 3.33e-06 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.